Arriving in Massachusetts with only his determination and artistic talent, Varoujan took menial, low-paying jobs as he learned English, his fifth language. He worked his way up through ten years as a journeyman billboard painter to pictorial artist for Akerley, the outdoor advertising giant. He is presently Art Director for Clear Channel .

Through AK Media, he has been involved with several highly visible art commissions and fund raisers. Joe Tecce's Restaurant in Boston's North End displays the Gallery of Grand Bostonians with 125 portraits, sketched by Varoujan, of citizens who have made an impact on Boston. His painting of the landmarks of Venice and the bounty of Italy brought to Boston covers four stories on Causeway Street at the gateway to the North End. Inside Filippo's Restaurant he painted a 6' x 20' mural in a realistic Renaissance style celebrating the 500th anniversary of Columbus' voyage to the Americas.

Relying on his classical training, Varoujan also creates religious works of art. His first major commission was for forty-six murals at St. Vartanantz Church in Chelmsford, the town he and his wife Gayane, daughter Betty, and son Armen have called home for over 10 years. Keeping with the Byzantine mural tradition of Armenia, Varoujan used vivid colors and iconography, but he introduced real-life features in portrait style for the religious figures. This work draws visitors from across the country and has led to other church commissions in Connecticut, New Jersey, and Wisconsin.